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" ... Yet to reduce the long-term unavailability of generic insulin to the present-day issue of biosimilarity is to miss the forest for the trees. Insulin is not a single product but a family of products: the original 1923 patent on insulin had already expired by the middle of the 20th century. By that time the insulin market had shifted to more stable versions patented in the 1940s and 1950s, like neutral protamine Hagedorn (NPH) and lente (“slow”) insulins. By the 1960s and 1970s, when these patents were expiring, a new series of patent-protected insulin products—“monocompetent” and “single peak” insulins—became popular. By the 1980s and 1990s, as these patents expired, insulin markets shifted to the new biotech insulin products: recombinant human insulin and insulin analogues. ... "