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" ... Other conditions: Coronary artery atherosclerosis, emphysema ... "
" ... The findings are notable, in part, because they challenge a 50 year old hypothesis made by Danish researchers that posited that high intake of marine animals rich in fish oil containing omega-3 fatty acids protected native Greenlandic Inuit peoples from atherosclerosis. However, the findings are not yet fully conclusive. The researchers are quick to point out that cardiovascular deaths were still rare among mid-20th century Inuit people. As the study points out, “The etiologic complexity of atherosclerosis confounds identification of single factors, such as omgea-3 fatty acids, as causal or protective.” Additionally, other factors may have contributed to the heart disease among the mummies studied including environmental smoke, produced by indoor fires used by Inuit communities, for example. ... "
" ... Until the results of a CAC RCT are available, use of either CAC or hsCRP as "tie-breakers" for determining statin benefit is reasonable. The 2010 ACCF/AHA Guideline For Assessment of Cardiovascular Risk in Asymptomatic Adults gives CAC scoring a IIa recommendation in the intermediate risk group and hsCRP measurement a IIa recommendation in those meeting the JUPITER entry criteria. However, we posit the provocative question - What is the future of primary prevention? Treating based on direct measurement of the disease we propose to treat (coronary atherosclerosis), or treating based on a single blood test? We look forward to future research in this area. ... "
" ... What began as an exciting area of drug discovery in 1990 has now come to an end. The quest for the “holy grail” of cardiovascular therapy -- a drug that dramatically lowered LDL-c and raised HDL-c and which would hopefully reverse atherosclerosis -- has ended ignominiously. In all likelihood, roughly $5 billion was spent on this quest by the key participants -- Pfizer, Merck, Lilly and Roche -- as well as others who sought CETP inhibitors. ... "