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" ... In the nucleocapsid protein, the aspartic acid to leucine mutation at position 3 (D3L) lies in the signal peptide, which drives the protein through the membrane. The nucleocapsid protein provides stability to the virus, antagonizes viral RNA and interferon responses, and inhibits genome replication in the host cell, thus a mutation to this region could enhance these critical processes. ... "
" ... This is not to say there are no escape variants that reduce binding and neutralization to the BG10-19 antibody. In fact, they found two mutations that reduce BG10-19’s neutralizing capability: G339R and L441P. The G339R mutation reduces neutralization as much as ten-fold and the L441P mutation reduces neutralization about one hundred-fold. While these mutations have not yet been sequenced and deposited into the GISAID mutation database, there have been other mutations at both positions. There have been 238 sequenced mutations at position 339, including changes to aspartic acid, serine, valine, as well as some deletions. Additionally, there have been 101 sequenced mutations at position 441, including changes to isoleucine, phenylalanine, arginine, as well as some deletions. While these are not the mutations that inhibit neutralization, their existence indicates that mutations to these positions are tolerated. ... "