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" ... The transcription of certain genes encoding enzymatic activity of specific compounds and metabolites was an early focus of research to define the molecular aspects of sleep deprivation. Compounds such as amylase and lipase, for example, have been found to serve as a good marker for acute sleep deprivation in humans at the population level. Such enzymatic activity may serve as a reflection of mitochondrial or oxidative stress. ... "
" ... “Food made with koji is the highest loaded enzyme product that one can produce very easily in your home”, says Shih. The primary enzymes in koji are amylase (it breaks down sugar), protease (it converts proteins into the amino acids) and lipase (it breaks fat into the fatty acids and alcohols). As a result, food fermented with koji contains plenty of umami and often a delicate sweetness too. ... "