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" ... The researchers also looked at the interval between patients' PET/CT scans and when they developed Takotsubo. They found that after their PET/CT scan, those with the highest amygdala activity developed the syndrome two years sooner, on average. "We found that among those who later developed Takotsubo, those with the very highest amygdalar activity actually developed Takotsubo earliest," Tawakol said. "They developed Takotsubo years earlier than individuals with lesser elevations of amygdalar activity, which suggests that it's not simply exposure to a rare stressor that determines the timing of Takotsubo." ... "