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" ... Achaogen’s drug, Plazomicin, has been supported by BARDA funding since 2010. So far, BARDA has provided $136 million to support the development of Plazomicin, including helping to pay for two phase 3 trials. Plazomicin belongs to the aminoglycoside class of antibiotics and provides a robust therapeutic option against serious bacterial infections that are multidrug resistant gram-negative bacteria, including carrbapenem-resistant Enterobacteriaceae (CRE). The drug was tested in blood stream infections (BSI) and complicated urinary tract infections (cUTI). In May an FDA Advisory panel was asked whether Achaogen’s drug showed “substantial evidence of safety and efficacy” in both BSI and cUTI. The panel voted unanimously (15-0) that it did for cUTI, but only voted 4-11 that it did for BSI. Regardless, the outcome is a huge success for BARDA as the company heads into a final decision on June 25th in two indications: Septicemia/Bacteremia (BSI) and Urinary Tract Tract Infections. Given the safety and clinical history of the drug to date, and the dire need for new drugs for doctors to turn to, we believe Plazomicin should be approved by the FDA. ... "