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" ... The paper is part of a special issue on allostery, an important biochemical process that was brand new in the early 1960s. Proteins are big molecules that have an “active site” that does most of their work (things like binding to other proteins or chemicals.) Allosteric regulation is what happens when another chemical binds somewhere other than the active site but still either make the protein more or less effective at doing whatever it is supposed to do. ... "