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" ... As an introduction, the two plant chemicals are called alkaloids, a broad term for nitrogen-containing compounds like caffeine from coffee. Mitragynine is the predominant alkaloid, 7-hydroxy is present in lower amounts, or not at all. More than 20 such alkaloids have been isolated from kratom. ... "
" ... While my reader feedback is not a scientific sample – and let me be the first to say that we should be as critical of these reports as I am of the FDA statement – recent work with kratom alkaloids and advances in our understanding of how opioid receptors work may partly account for kratom's anecdotal reports of utility and relative safety. (At the very least, these reports would lead me to want to conduct a randomized, controlled clinical trial of a well-qualified kratom product in patients with chronic pain, or to compare it head-to-head with prescription medication-assisted therapy for opioid dependence.) ... "
" ... “Plants may form alkaloids when they are under pressure,” he said. “In high quantities they could be poisonous to us. We will check on them later, to see if any of them are in the crops, together with vitamins." ... "