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" ... In initiating an anti-addiction medication, for example, doctors evaluate the likelihood that a patient who requests naltrexone is likely to complete a week-long detox, an essential aspect of the preparation for treatment with it. (In the Lee et al, study, a full quarter of those randomized to the naltrexone group, could not make it through) We consider whether a patient would do perhaps better on methadone, an opioid medication, a full agonist, with a track record of more than 50 years. We work with patients who don’t want any medication. We assess the person’s degree of social support, housing stability, and so on. ... "
" ... The FDA said that the safety and efficacy of Trulicity, a glucagon-like peptide-1 (GLP-1) receptor agonist, had been studied in 3,342 type 2 diabetics. The drug can be given as monotherapy or in combination with other diabetes drugs including metformin, sulfonylurea, thiazolidinediones, and prandial insulin. It is not indicated for use in type 1 diabetics, in people with diabetic ketoacidosis, or in people with severe intestinal problems. It should not be used as initial therapy in diabetics who cannot be managed with diet and exercise. ... "