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" ... In other words, Pfizer and Moderna have created a Lamborghini when what most countries really need is a Toyota—a vaccine that can be manufactured, stored, and administered simply and cheaply, preferably via existing distribution channels. Luckily, such alternatives exist. One is the adenovirus vaccine being developed by companies like AstraZeneca and Johnson & Johnson, which uses a nonlethal cold-causing viral vector as its means of inoculation, rather than synthetic proteins as mRNA vaccines do. Adenovirus vaccines are, however, hampered by one deep and fundamental flaw. Recipients would risk developing immunity not just to Covid-19, but the vector itself, meaning after initial rounds of rollout, another candidate might have to be developed from scratch. The AstraZeneca vaccine and others of its ilk can be thought of as Mercedes—not as high-maintenance as a Lamborghini, but certainly not as practical as a Toyota. ... "
" ... The Oxford-AstraZeneca vaccine also helps your cells manufacture the spike protein, but does so differently. Instead of mRNA encapsulated in a coating, the Oxford-AstraZeneca vaccine instead uses another virus, an adenovirus, to essentially serve as an Uber carrying spike protein-related double-stranded DNA to your cells. Once plopped inside your cells, the DNA can serve as a library for your cells to generate mRNA, which in turn codes for the spike protein. ... "
" ... This vaccine works differently than the mRNA vaccines that have already been authorized. Instead of injecting strands of mRNA into patients, the Johnson & Johnson vaccine injects a harmless virus with DNA inside. The virus is a modified adenovirus, from a family of viruses that causes the common cold, but it won’t make you sick. Instead, it delivers the DNA into cells within the body. Once inside, the DNA instructs the cells to make copies of the spike protein that is on the Covid-19 virus. These spike proteins train the immune system to look out for similar proteins, priming antibodies to fight against Covid-19. If the Covid-19 virus ever enters the body, the immune system will recognize it and be ready to fight it off. ... "
" ... Unlike mRNA vaccines, the Johnson & Johnson/Oxford-AstraZeneca class of vaccines rely on a type of virus called adenovirus which is known to cause colds in chimpanzees. To address COVID-19, the adenovirus delivers the DNA coding for the SARS-CoV-2 spike protein into the cells. When the cells read the instructions, they produce the spike protein (though not the full virus) which triggers the body make antibodies. Like mRNA vaccines, adenovirus-based vaccines essentially train the body to recognize and fight COVID-19, foregoing the need to inject a person with a weakened version of SARS-CoV-2. ... "
" ... What then is the argument for pressing forward with the adenovirus vector SARS-CoV-2 spike protein vaccine? ... "