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" ... These types of targets are certainly not unique to Atlas; other early stage VCs invest in companies and targets with similar human genetic profiles. For example, Third Rock Venture’s portfolio has a number of targets validated through “tail” variations in gene function: Agios’ inborn error of metabolism program acround PKR, MyoKardia’s focus on myosin in hypertrophic cardiomyopathy, Global Blood’s aim to augment mutant hemoglobin’s oxygen binding, etc… Similar portfolios can presumably be found elsewhere in the early stage venture community. ... "